https://michaelpatrickhughes.com/home daily 1.0 2021-09-27 https://michaelpatrickhughes.com/science daily 0.75 2021-06-25 https://images.squarespace-cdn.com/content/v1/6030361edb4f7c6c776f6bce/1614203612906-W2CNKD2A3O18P9Y9OSVK/larks-iamges-longer.png Science https://images.squarespace-cdn.com/content/v1/6030361edb4f7c6c776f6bce/1624584387219-S5C633EPKRX4S2IPU7GX/hnRNPA2-comp1.png Science - Make it stand out Above is a representation of hnRNPA2 determined by cryoEM as determined in Lu et al., 2020. PDBID 6WQK. Below is the structure of luciferase colored by a propensity to form steric zippers as judged by zipperDB. https://images.squarespace-cdn.com/content/v1/6030361edb4f7c6c776f6bce/1614123563980-6TXBXN5RAIX0O1SDYWWO/stericZipperPdb-example.png Science https://images.squarespace-cdn.com/content/v1/6030361edb4f7c6c776f6bce/1614123472564-04411S1885H0EK4LN4F6/drawing-draft3.png Science https://michaelpatrickhughes.com/art daily 0.75 2021-09-15 https://images.squarespace-cdn.com/content/v1/6030361edb4f7c6c776f6bce/2bc66037-ced8-4b48-9515-d3ffe23707c4/Image0172.png Art https://images.squarespace-cdn.com/content/v1/6030361edb4f7c6c776f6bce/56fa88ba-3210-4aa7-88a8-bff10e0e587c/cb1-vaporWave-small.png Art G-protein receptor with cutaway to reveal the molecule in the binding pocket. https://images.squarespace-cdn.com/content/v1/6030361edb4f7c6c776f6bce/978923ad-a1ad-47c4-8446-897e661363bd/darkForest-2.png Art The Dark Forest A proteasome is a protein dedicated to degrading other proteins. Here one is pictured in a forest of misfolded proteins called amyloid fibrils. These fibrils are associated with amyloid diseases like ALS, Alzheimer's disease, and Frontotemporal Dementia. https://images.squarespace-cdn.com/content/v1/6030361edb4f7c6c776f6bce/07d9c411-90dc-4dce-a752-3ce8e22a33c3/g3bp1-vcp-marked.png Art Unraveling cellular stress Cells under stress may form stress granules. These granules are mixtures of proteins and RNA that separate from the cytoplasm, and eventually re-integrate into the cell when the stress passes. A protein called VCP (green) helps unravel these granules, pulling them apart. Failure to dissolve stress granules after stress passes may be linked to ALS parthenogenesis. https://images.squarespace-cdn.com/content/v1/6030361edb4f7c6c776f6bce/efab391c-1a0d-498c-857d-db73047ceca8/vcp-concept-final5-small.jpg Art https://images.squarespace-cdn.com/content/v1/6030361edb4f7c6c776f6bce/63cf8776-4958-4d01-9c07-890d84a30f6b/sceneMyoglobin-marked.png Art Myoglobin Myoglobin (red) transports oxygen in the blood with the help of iron. Hemoglobin is a similar protein that transports oxygen in blood. The difference is that myoglobin binds oxygen more tightly than hemoglobin, but why have both? Infants developing in the womb use myoglobin while mothers (and the rest of us) use hemoglobin. Since myoglobin in the infant can bind oxygen more tightly than the hemoglobin of their mother, the oxygen can flow into the unborn child. https://images.squarespace-cdn.com/content/v1/6030361edb4f7c6c776f6bce/888b93eb-e0d6-48a6-9581-1b1151a456a8/hnRNPA2-marked.png Art https://images.squarespace-cdn.com/content/v1/6030361edb4f7c6c776f6bce/33661c8e-829a-4ddf-8023-e59452279bf6/hydrogel-depth.png.png Art https://images.squarespace-cdn.com/content/v1/6030361edb4f7c6c776f6bce/1613956751388-BLFECVQMVMWWN9IV0AS3/retroReceptor-draft3.jpg Art Cannabinoid Receptor The cannabinoid receptor is one of the most numerous G protein-coupled receptors (GPCRs) in the body. GPCRs are a family of proteins that transmit a signal from the outside of the cell to the inside. Some 800 different GPCRs are important all over the body to mediate diverse functions such as sight, adrenaline response, smell, and your bodies response to cannabis. This is an interpretation of the human cannabinoid GPCR as determined by Cryogenic Electron Microscopy (PDBID 6N4B). https://images.squarespace-cdn.com/content/v1/6030361edb4f7c6c776f6bce/48de90e5-a75d-474d-9e0d-36974f0c2e93/untitled3.png Art https://images.squarespace-cdn.com/content/v1/6030361edb4f7c6c776f6bce/0e1c6eee-16c3-46e2-94be-7570d1ce47c9/brushedmetal7.png Art https://images.squarespace-cdn.com/content/v1/6030361edb4f7c6c776f6bce/a3c800a9-86e4-4e3e-95a6-7b53d6e89cc8/ATPsynthetase.png Art https://images.squarespace-cdn.com/content/v1/6030361edb4f7c6c776f6bce/92ad6f01-031b-4a12-a00a-c16704828893/ATPsynthetaseImage.png Art https://michaelpatrickhughes.com/about daily 0.75 2021-10-16 https://images.squarespace-cdn.com/content/v1/6030361edb4f7c6c776f6bce/1634414772903-ARKAZ5EXVO80VQ9GJSLK/PXL_20211015_175027171.jpg MPH - About https://michaelpatrickhughes.com/home-1 daily 0.75 2025-05-12 https://images.squarespace-cdn.com/content/v1/5cec314da9fd45000100ce45/1562791491607-X4SEQNVHUUVLPBUC6MDX/image-asset.png Home - Canvas Drip / 1 of 6 Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt. https://images.squarespace-cdn.com/content/v1/5cec314da9fd45000100ce45/1562791583614-NN8L86GN7EGBD9Q7TOSK/2.jpg Home - Canvas Drip / 2 of 6 Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt. https://images.squarespace-cdn.com/content/v1/5cec314da9fd45000100ce45/1562791627957-J3MD5D7ZLK0LDFU9S9D1/3.jpg Home - Canvas Drip / 3 of 6 Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt. https://images.squarespace-cdn.com/content/v1/5cec314da9fd45000100ce45/1562791689996-85O6V28GEB2E3RIYAAQV/4.jpg Home - Canvas Drip / 4 of 6 Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt. https://images.squarespace-cdn.com/content/v1/5cec314da9fd45000100ce45/1562791713984-VKTU6CKPYVI1DLBE43JM/5.jpg Home - Canvas Drip / 5 of 6 Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt. https://images.squarespace-cdn.com/content/v1/5cec314da9fd45000100ce45/1562791742978-T27Z6L3ZNARVFLKPF2Z0/6.jpg Home - Canvas Drip / 6 of 6 Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt.